HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 2,3-Epoxypropyl 4-(n-hexadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Cetaben Sodium | HCID 23703815 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,3-Epoxypropyl 4-(n-hexadecylamino)benzoate | HCID 13019377 | — |
Reaction Conditions
| Temperature | 105 °C |
|---|
Reaction Steps
A mixture of 89.0 g of epichlorohydrin, 92.0 g of sodium 4-(n-hexadecylamino)benzoate, and 350 ml of hexamethylphosphoramide is stirred at 105° C for 5 hours, allowed to cool, and poured into 1.0 liter of water. The white solid is collected by filtration, recrystallized from acetonitrile and then from hexane-methylene chloride to yield 2,3-epoxypropyl 4-(n-hexadecylamino)benzoate, mp 86°-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04058550 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-e5fe01e5a898423e95a41147afef1c34 |
| Source note | uspto-grants-1977_11 |