Acetic Anhydride → HCID 21326939, compound

HRID 1439288Notes

Reaction equation

HRID 1439288 reaction equation
[CH2:1]([NH:17][C:18]1[CH:31]=[CH:30][C:21]([C:22]([O:24][CH2:25][CH:26]([OH:29])[CH2:27][OH:28])=[O:23])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C(O[C:36](=[O:38])[CH3:37])(=O)C>C(Cl)(Cl)Cl>[C:22]([N:17]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:18]1[CH:19]=[CH:20][C:21]([C:22]([O:24][CH2:25][CH:26]([O:29][C:36](=[O:38])[CH3:37])[CH2:27][O:28][C:25](=[O:24])[CH3:26])=[O:23])=[CH:30][CH:31]=1)(=[O:23])[CH3:21]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 130193802,3-Dihydroxypropyl 4-(n-hexadecylamino)benzoate

Product 1

HCID 21326939HCID 21326939, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 6.53 g of 2,3-dihydroxypropyl 4-(n-hexadecylamino)benzoate in 100 ml of chloroform is stirred under reflux while 9.0 ml of acetic anhydride is added and for 6 hours thereafter. The solution is extracted with 2% aqueous sodium carbonate solution and water, dried, and evaporated to yield 2,3-diacetoxypropyl N-acetyl-4-(n-hexadecylamino)benzoate as a yellow oil.

Workup

  1. additionis added and for 6 hours
  2. extractionThe solution is extracted with 2% aqueous sodium carbonate solution and water
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-0f1191e5f42b485486863c12529a82e2
Source dataset
uspto-grants-1977_11
Patent number
US04058550

Reaction notes

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