HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 4-Hydroxy-2-buten-1-yl 4-(n-hexadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 2-Butene-1,4-diol | HCID 8065 | — |
| Reactant | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Hydroxy-2-buten-1-yl 4-(n-hexadecylamino)benzoate | HCID 53942674 | — |
Reaction Steps
To a mixture of 8.8 g. of 1,4-dihydroxy-2-butene and 2.84 g. of 4-dimethylaminopyridine is added 4.16 g. of 4-(n-hexadecylamino)benzoyl chloride hydrochloride. The heat evolution is moderated with ice and stirring is continued for 4 hours. Chloroform and water are added and the chloroform extract chromatographed to remove any diacylated by-product. Evaporation to crystallization yields the 4-hydroxy-2-buten-1-yl 4-(n-hexadecylamino)benzoate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04058550 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-8f558aa388aa4f7597f042d1a962c691 |
| Source note | uspto-grants-1977_11 |