反应详情

A mixture of 3.8 g of 1,1-dimethyl-3-(4-cyano-3-ethoxy-5-isothiazolyl)urea in 7 ml of concentrated sulfuric acid was treated as described in Example II to give 3.5 g of 1,1-dimethyl-3-(4-carbamoyl-3-ethoxy-5-isothiazolyl)urea, m.p. 172°-172°. The nmr spectrum was consistent with the assigned structure.

1. additionwas treated