Hydrogen Peroxide → 5-Amino-4-cyano-3-isopropoxyisothiazole

Participants

Reaction Steps

In the manner of Example V C, 123 g of 3-amino-2-cyano-3-isopropoxy-2-propenethioamide in 500 ml of isopropanol were treated with 80 ml of 30% hydrogen peroxide (22.6 g of active H2O2). The residue from the reaction was recrystallized from toluene to yield 108.4 g of 5-amino-4-cyano-3-isopropoxyisothiazole, mp 146°-148°. The nmr and ir spectra were consistent with the assigned structure.

Provenance & Evidence