Phenoxyacetic Acid → HCID 54113420, compound

Participants

Reaction Steps

To a solution of potassium (5R,6R)-2,2-dimethyl-6-phenoxyacetamidopenam-3-carboxylate (10 g, 25.7 mM) and phenoxyacetic acid (2 g, 13.1 mM) in water (100 ml) was added a solution of diphenyldiazomethane (5.2 g, 27 mM) in dichloromethane (100 ml). The pH was adjusted to 4.0 and the mixture stirred for 10 minutes. After separation, the solvent was washed with water (100 ml), 5% w/v sodium bicarbonate solution (100 ml) and water (100 ml). The solvent was removed in vacuo to give the title compound (11.4 g).

Provenance & Evidence