Isopropanol → N~1~-[3-(Piperidin-1-yl)propyl]benzene-1,2-diamine

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Reaction Steps

The balance of the 2-[3-(1-piperidinyl)propylamino]nitrobenzene was reduced to the corresponding N-substituted o-phenylenediamine by means of stannous chloride in concentrated hydrochloric acid as described in Example 1 for the corresponding 4-methylpiperazino compound. The product, N-[3-(1-piperidinyl)propyl]-o-phenylenediamine, was isolated as the hydrochloride salt by crystallization from isopropanol, m.p. 208°-210° C.

Provenance & Evidence