Phosphorus pentachloride → HCID 2770500, compound

HRID 1439375Notes

Reaction equation

HRID 1439375 reaction equation
[ClH:1].[NH:2]=[C:3]1[N:7]([CH2:8][CH:9](OC(=O)C)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:6][CH2:5][S:4]1.P(Cl)(Cl)(Cl)(Cl)[Cl:21]>C(Cl)(Cl)Cl>[ClH:21].[NH:2]=[C:3]1[N:7]([CH2:8][CH:9]([Cl:1])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:6][CH2:5][S:4]1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 21397211HCID 21397211, compound

Product 1

HCID 2770500HCID 2770500, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The 2-imino-3-(2'-acetoxy-2'-phenylethyl)thiazolidine hydrochloride (0.01 mole) was heated under reflux with phosphorus pentachloride for one hour in chloroform (5 ml). The solvent was evaporated to leave a colourless solid which was crystallised from ethanol, yield 1.9 g. This compound was used in the synthesis of the compound of Example 75 as described for the corresponding 2-imino derivative in Example 75 Method A.

Workup

  1. customThe solvent was evaporated
  2. customto leave a colourless solid which
  3. customwas crystallised from ethanol, yield 1.9 g
  4. customThis compound was used in the synthesis of the compound of Example 75

Sources & evidence

ORD record
ord-93263f018ffc4f3282d154ff64048a68
Source dataset
uspto-grants-1977_11
Patent number
US04059588

Reaction notes

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