Tetrahydrofuran → HCID 21397490, compound

Participants

Reaction Steps

0.5 Gm. of 2-(5-bromo-5H-dibenzo[a,d]cyclohepten-2-yl)propionic acid is refluxed for 3 hours in 10 ml. of tetrahydrofuran and 25 ml. of water containing 0.5 gm. of sodium carbonate. The solution is cooled and washed with ether. The aqueous solution is then acidified with 0.5 N hydrochloric acid and extracted with ethyl acetate. The extract is washed, dried and evaporated to afford a 40% yield of 2-(5-hydroxy-5H-dibenzo[a,d]cyclohepten-2-yl)propionic acid.

Provenance & Evidence