4-Chloro-2-toluidine → N-(2-chloroethyl) N'-(4-chloro2-methylphenyl)urea

Participants

Reaction Steps

A solution of 2-chloroethyl isocyanate, 28.3 g. (0.27 mole) in 100 ml. of ether is added dropwise to a solution of 4-chloro-2-methylaniline, 38.0 g. (0.27 mole), in 500 ml. of ether. The solution is stirred 16 hours at room temperature, and the solid product is filtered and air dried, giving 47.2 g. (71% of theory) of the desired product, m.p. 190°.

Provenance & Evidence