反应详情

温度

25 °C

A stirred slurry of 10.0 g. (0.028 mol.) of 2-benzoyl-3-bromomethylquinoxaline 1,4-dioxide in 1,000 ml. of water was heated under reflux for 18 hours. The hot reaction mixture was filtered, and the filtrate was allowed to cool to 25° C. The solid which precipitated was collected by filtration to provide a first crop of crude product. The aqueous filtrate was extracted with dichloromethane, which was then dried and evaporated in vacuo, to provide a second crop of crude product. The combined crude product was 7.0 g. (85% yield). It was recrystallized from ethanol to give 4.9 g. (59% yield) of 2-benzoyl-3-hydroxymethylquinoxaline 1,4-dioxide having m.p. 178°-179° C.

1. temperatureunder reflux for 18 hours
2. filtrationThe hot reaction mixture was filtered
3. customThe solid which precipitated
4. filtrationwas collected by filtration
5. customto provide a first crop of crude product
6. extractionThe aqueous filtrate was extracted with dichloromethane, which
7. customwas then dried
8. customevaporated in vacuo
9. customto provide a second crop of crude product
10. customIt was recrystallized from ethanol
11. customto give 4.9 g