참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 3-Pentenenitrile, Pract. | HCID 20750 | — |
| 촉매 | Dicobalt Octacarbonyl (stabilized with 1-5% Hexane) | HCID 25049 | — |
| 용매 | HCID 178418416 | HCID 178418416 | — |
| 생성물 | Methyl 5-cyanopentanoate | HCID 554130 | 70.1% |
반응 단계
An argon-filled shaking autoclave is charged with a mixture of 8.1 parts of 3-pentenonitrile, 1.4 parts of dicobalt octacarbonyl, 2.6 parts of pyridine, 8 parts of methanol and 30 parts of tetrahydrofuran. The pressure is brought to 140 bars by forcing in carbon monoxide at room temperature. The autoclave is next heated to 160° C; the pressure is then brought to 200 bars by forcing in carbon monoxide, and the reaction mixture is shaken for 4 hours under these conditions. After cooling, and letting down the pressure, the mixture is filtered. Fractional distillation of the reaction mixture gives 9.9 parts of 5-cyanovaleric acid methyl ester (70.1% of theory). Boiling point 118°-120° C/10 mm Hg, nD20 = 1.4322.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04060543 |
|---|
| 출처 데이터셋 | uspto-grants-1977_11 |
|---|
| ORD ID | ord-7ec56ffe3dbc44b682a7313dd9ccf11e |
|---|
| 출처 메모 | uspto-grants-1977_11 |
|---|
