HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1439581Generated: October 31, 2026
Methyl Bromide → 2-(4-(Thien-2-ylcarbonyl)phenyl)propiononitrile
https://huagongshe.com/reaction/1439581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl Bromide | HCID 6323 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-[p-(2-Thenoyl)phenyl]acetonitrile | HCID 12232974 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-(Thien-2-ylcarbonyl)phenyl)propiononitrile | HCID 103686 | — |
Reaction Steps
11.4 parts of 2-[p-(2-thenoyl)phenyl]acetonitrile, 4.9 parts of methyl bromide and 0.13 parts of benzyl triethyl ammonium chloride are added to 30 parts of a 50% sodium hydroxide solution. The whole is stirred vigorously for 5 hours at 35° C. Distilled water is added. The organic layer is separated, washed with distilled water and evaporated. The oily residue is distilled, yielding p-(2-thenoyl)hydratroponitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04060528 |
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| Source dataset | uspto-grants-1977_11 |
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| ORD ID | ord-0c46f295c5084b1ebf8758b03822951c |
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| Source note | uspto-grants-1977_11 |
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