Ammonium Hydroxide → Morpholine, 4-(2-((2-(4-phenyl-1-piperazinyl)ethyl)amino)benzoyl)-, monohydrochloride

Participants

Reaction Steps

o-Aminobenzoylmorpholine (9 g), 14 g phenylpiperazinoethyl chloride hydrochloride, 12 g sodium acetate, and 50 ml water were refluxed 24 hours. The reaction was cooled to 30°, 100 ml water and 100 ml NH4OH added and the liquid decanted. The solid was stirred with 125 ml hot 60% propanol and filtered. The solid was dissolved in 1 liter of ether and 120 ml methanol and a solution of HCl gas in ether added to give 6.1 g, m.143-5°.

Provenance & Evidence