Ammonia → 5-Hydroxy-2-nitrobenzamide

HRID 1439607Notes

Reaction equation

HRID 1439607 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7](OC)=[O:8].[NH3:15]>CO>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7]([NH2:15])=[O:8]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12922678Methyl 5-hydroxy-2-nitrobenzoate

Product 1

HCID 205723945-Hydroxy-2-nitrobenzamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 5-hydroxy-2-nitrobenzoate (48 g) in 340 ml methanol was heated 30 hours at 107° in a pressure vessel with 140 ml NH3. The mixture was cooled and concentrated to dryness on the rotovap. Water was added (200 ml) and the solid filtered and dried to give 12 g product, m.135-8°.

Workup

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated to dryness on the rotovap
  3. additionWater was added (200 ml)
  4. filtrationthe solid filtered
  5. customdried

Sources & evidence

ORD record
ord-6b2f0804a0af4925ae7e7073294531dd
Source dataset
uspto-grants-1977_11
Patent number
US04060526

Reaction notes

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