反应详情

Methyl 5-hydroxy-2-nitrobenzoate (48 g) in 340 ml methanol was heated 30 hours at 107° in a pressure vessel with 140 ml NH3. The mixture was cooled and concentrated to dryness on the rotovap. Water was added (200 ml) and the solid filtered and dried to give 12 g product, m.135-8°.

1. temperatureThe mixture was cooled
2. concentrationconcentrated to dryness on the rotovap
3. additionWater was added (200 ml)
4. filtrationthe solid filtered
5. customdried