Potassium Hydroxide → HCID 20390570, compound

HRID 1439715Notes

Reaction equation

HRID 1439715 reaction equation
C([O:4][CH2:5][CH:6]([N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)[CH2:7][O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1)(=O)C.[OH-].[K+]>CO.O>[N:19]1([CH:6]([CH2:7][O:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][CH:10]=2)[CH2:5][OH:4])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 53915022HCID 53915022, compound

Product 1

HCID 20390570HCID 20390570, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

A suspension of 2-piperidino-3-(1-naphthyloxy)-1-propanol acetate (6.4 g), 15% KOH in methanol (10 ml), methanol (10 ml) and water (20 ml) is heated at reflux for 1 hour. The reaction mixture is concentrated to dryness. The residue is taken up in diethyl ether. The ether extract is washed with water and concentrated to give the title compound as an oil, γmaxEtOH 319 nm (ε = 1780), 305 nm (ε = 3330), 288 nm (ε = 6340), 230 nm (ε = 30,600), 212 nm (ε = 44,180).

Workup

  1. temperatureis heated
  2. temperatureat reflux for 1 hour
  3. concentrationThe reaction mixture is concentrated to dryness
  4. extractionThe ether extract
  5. washis washed with water
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-88f1c7014f584a82a93927f00d205ec9
Source dataset
uspto-grants-1977_11
Patent number
US04060613

Reaction notes

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