2-Chloro-6,7-dimethoxy-4-quinazolinamine → 4-Amino-2-[4-(1-cyclopenten-1-ylcarbonyl)piperazinyl]-6,7-dimethoxyquinazoline

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Reaction Steps

N-(1-cyclopenten-1-ylcarbonyl)piperazine (1.8 g., 0.01 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (2.4 g., 0.01 mole) are reacted according to the procedure of Example 1(a). The isolated product crystallized from methanol affords analytically pure 4-amino-2-[4-(1-cyclopenten-1-ylcarbonyl)piperazinyl]-6,7-dimethoxyquinazoline, m.p. 256.5°-258.0° C. (corr.).

Provenance & Evidence