2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 21396259, compound

HRID 1439726Notes

Reaction equation

HRID 1439726 reaction equation
[CH:1]1([C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[O:7])[CH2:5][CH:4]=[CH:3][CH2:2]1.Cl[C:15]1[N:24]=[C:23]([NH2:25])[C:22]2[C:17](=[CH:18][C:19]([O:28][CH3:29])=[C:20]([O:26][CH3:27])[CH:21]=2)[N:16]=1>>[NH2:25][C:23]1[C:22]2[C:17](=[CH:18][C:19]([O:28][CH3:29])=[C:20]([O:26][CH3:27])[CH:21]=2)[N:16]=[C:15]([N:11]2[CH2:10][CH2:9][N:8]([C:6]([CH:1]3[CH2:2][CH:3]=[CH:4][CH2:5]3)=[O:7])[CH2:13][CH2:12]2)[N:24]=1

Participants

3

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 21184018HCID 21184018, compound

Product 1

HCID 21396259HCID 21396259, compound

Procedure

N-(3-cyclopentenylcarbonyl)piperazine (2.7 g., 0.015 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (3.6 g., 0.015 mole) are reacted according to the procedure of Example 1(a). The crude product crystallized from methanol affords analytically pure 4-amino-2-[4-(3-cyclopentenylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 215.5°-217.5° C. (corr.).

Workup

  1. customThe crude product crystallized from methanol

Sources & evidence

ORD record
ord-2b93b83432544792be136de605ded65d
Source dataset
uspto-grants-1977_11
Patent number
US04060615

Reaction notes

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