2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 21183925, compound

HRID 1439727Notes

Reaction equation

HRID 1439727 reaction equation
[CH:1]1([C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:8])[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.Cl[C:16]1[N:25]=[C:24]([NH2:26])[C:23]2[C:18](=[CH:19][C:20]([O:29][CH3:30])=[C:21]([O:27][CH3:28])[CH:22]=2)[N:17]=1>>[NH2:26][C:24]1[C:23]2[C:18](=[CH:19][C:20]([O:29][CH3:30])=[C:21]([O:27][CH3:28])[CH:22]=2)[N:17]=[C:16]([N:12]2[CH2:11][CH2:10][N:9]([C:7]([CH:1]3[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]3)=[O:8])[CH2:14][CH2:13]2)[N:25]=1

Participants

3

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 21183946HCID 21183946, compound

Product 1

HCID 21183925HCID 21183925, compound

Procedure

N-(3-cyclohexenylcarbonyl)piperazine (7.65 g., 0.04 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (9.6 g., 0.04 mole) are reacted according to the procedure of Example 1(a). The crude product crystallized from methanol affords analytically pure 4-amino-2-[4-(3-cyclohexenylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 211°-213° C. resolidifying and melting at 234.0° -236.0°C. (corr.).

Workup

  1. customThe crude product crystallized from methanol

Sources & evidence

ORD record
ord-08253e49c7bf41f29024c9aad8f2c07e
Source dataset
uspto-grants-1977_11
Patent number
US04060615

Reaction notes

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