2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 21183995, compound

HRID 1439729Notes

Reaction equation

HRID 1439729 reaction equation
[CH:1]1([C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:16][C:17]1[N:26]=[C:25]([NH2:27])[C:24]2[C:19](=[CH:20][C:21]([O:30][CH3:31])=[C:22]([O:28][CH3:29])[CH:23]=2)[N:18]=1>>[ClH:16].[NH2:27][C:25]1[C:24]2[C:19](=[CH:20][C:21]([O:30][CH3:31])=[C:22]([O:28][CH3:29])[CH:23]=2)[N:18]=[C:17]([N:13]2[CH2:12][CH2:11][N:10]([C:8]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]3)=[O:9])[CH2:15][CH2:14]2)[N:26]=1

Participants

3

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 21183973HCID 21183973, compound

Product 1

HCID 21183995HCID 21183995, compound

Procedure

N-(Cycloheptylcarbonyl)piperazine (0.02 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (0.02 mole) are reacted according to the procedure of Example 7. Crystallization of the product from methanol-isopropanol provides analytically pure 4-amino-2-[4-(cycloheptylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline hydrochloride, m.p. 278°-279° C. (corr.).

Workup

  1. customCrystallization of the product from methanol-isopropanol

Sources & evidence

ORD record
ord-dd33fb3a01fa4fedb85e612f6b5fcc9d
Source dataset
uspto-grants-1977_11
Patent number
US04060615

Reaction notes

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