Ethanol → HCID 178525838, compound

HRID 1439736Notes

Reaction equation

HRID 1439736 reaction equation
C([N:6]([CH3:13])[NH:7][C:8]([NH:10][CH:11]=O)=[S:9])(OCC)=O.[OH-:14].[K+].S(=O)(=O)(O)O.[CH2:21]([OH:23])C>>[C:21]([CH2:11][N:10]1[CH:13]=[N:6][N:7]=[C:8]1[SH:9])([OH:23])=[O:14]

Participants

5

Reactant 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 14797Potassium HydroxideHCID 86734112HCID 86734112, compound

Product 1

HCID 178525838HCID 178525838, compound

Procedure

1-carbethoxy-methyl-4-formylthiosemicarbazide (0.50 g., 2.44 mmol.) was dissolved in 5 ml. of ethanol and 5 ml. (2 equivalents) of aqueous potassium hydroxide solution was added. The reaction mixture was refluxed for five hours then cooled, acidified to pH 2.0 with 6N sulfuric acid and evaporated to dryness. The residue was extracted with acetone to give 4-carboxymethyl-1,2,4-triazole-3-thiol.

Workup

  1. temperatureThe reaction mixture was refluxed for five hours
  2. temperaturethen cooled
  3. customevaporated to dryness
  4. extractionThe residue was extracted with acetone

Sources & evidence

ORD record
ord-f32c3d8c8a324b8da3ac5324153c0116
Source dataset
uspto-grants-1977_11
Patent number
US04060610

Reaction notes

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