HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 21331125, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2,2-Diethylpropanedioate | HCID 6951563 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21331125 | HCID 21331125 | — |
Reaction Steps
To a solution of 13.8 g. (0.6 mol.) of sodium in absolute ethanol is added a solution of 96 g. (0.6 mol.) of diethylmalonate in 500 ml. of ether. The mixture is cooled and 117.1 g. (0.6 mol.) of 2-bromo-2-methylpropionic acid ethyl ester is added. The reaction mixture is warmed for two hours, then stirred at ambient temperature for 48 hours. Acetic acid and water are added, the layers are separated and the ethereal phase is washed with water, dried (MgSO4) and evaporated to dryness to give diethyl 2-(1-carbethoxy-1-methylethyl)malonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04060610 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-a67c7a30d3d24928ade5eeb4539f133a |
| Source note | uspto-grants-1977_11 |