Acetonitrile → HCID 178485013, compound

HRID 1439745Notes

Reaction equation

HRID 1439745 reaction equation
Br[C:2]1[C:3]([CH2:8][S:9][CH2:10][CH2:11][NH2:12])=[N:4][CH:5]=C[CH:7]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:23][C:24](=[N:27][CH3:28])SC)(=[O:22])=[O:21])=[CH:16][CH:15]=1.C(#[N:31])C>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:23][C:24]([NH:27][CH3:28])=[N:12][CH2:11][CH2:10][S:9][CH2:8][C:3]2[NH:4][CH:5]=[N:31][C:2]=2[CH3:7])(=[O:22])=[O:21])=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 129515272-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amineHCID 22756462N-(4-chlorobenzenesulphonyl)-N',S-dimethylisothiourea

Product 1

HCID 178485013HCID 178485013, compound

Procedure

A solution of 3-bromo-2((2-aminoethyl)thiomethyl)pyridine (5.0 g) and N-(4-chlorobenzenesulphonyl)-N',S-dimethylisothiourea (5.4 g) in acetonitrile was heated under reflux for 24 hours. Concentration followed by recrystallisation afforded N-(4-chlorobenzenesulphonyl)-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine.

Workup

  1. temperatureunder reflux for 24 hours
  2. concentrationConcentration
  3. customfollowed by recrystallisation

Sources & evidence

ORD record
ord-12fa8cf543f2448fbcea6bde5c95a68a
Source dataset
uspto-grants-1977_11
Patent number
US04060621

Reaction notes

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