2-[N-(2,5-dichlorophenyl)-N-(beta-diethylaminoethyl)amino]acetophenone → HCID 21396395, compound

Participants

Reaction Steps

A solution of 0.10 mole of 2-[N-(2,5-dichlorophenyl)-N-(β-diethylaminoethyl)amino]acetophenone in 200 ml of dry diethylether is added to a solution of 0.10 mole of methylmagnesium iodide in 500 ml of dry diethylether maintained at a temperature of from 0° to -5° C under nitrogen atmosphere. Thirty minutes after the addition the reaction mixture is washed with ice cold aqueous 2M ammonium chloride, dried over sodium sulfate, filtered and evaporated to give N-(β-diethylaminoethyl)-N-(β-hydroxy-β-phenylpropyl)-2,5-dichloroaniline.

Provenance & Evidence