HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 1-Cyano-3-(4'-fluoro-4-biphenylyl)-butan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-Chloro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol | HCID 20302896 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-Cyano-3-(4'-fluoro-4-biphenylyl)-butan-3-ol | HCID 21396473 | — |
Reaction Steps
A solution of 27.9 g. of 1-chloro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol in 60 ml. of dimethylsulfoxide is added, at 80°, to a solution of 7.6 g. of NaCN in 100 ml. of dimethylsulfoxide. The mixture is warmed to 80°-90° for 6 hours, poured onto ice and worked up in the customary manner to give 1-cyano-3-(4'-fluoro-4-biphenylyl)-butan-3-ol, m.p. 118°-120°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04060633 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-63c8ba5920a94058a8589f9c5fcba36a |
| Source note | uspto-grants-1977_11 |