Hydrochloric Acid → HCID 21396531, compound

Participants

Reaction Steps

2.78 g. of 1-chloro-3-(4'-amino-4-biphenylyl)-butan-3-ol are dissolved in 30 ml. of 10% hydrochloric acid, a solution of 0.7 g. of NaNO2 in 2 ml. of water is added at 0°-5°, the resulting diazonium salt solution is added slowly dropwise to a hot solution of Cu2Cl2 (obtained by passing SO2 into a hot solution of 2.1 g. of copper sulfate and 2.6 g. of NaCl in 13 ml. of water) and the mixture is heated to 90°-95° for a further 30 minutes, cooled and worked up in the customary manner to give 1-chloro-3-(4'-chloro-4-biphenylyl)-butan-3-ol, m.p. 98° - 100°.

Provenance & Evidence