Potassium Cyanide → 1-Cyano-3-(4'-fluoro-4-biphenylyl)-butan-3-ol

Participants

Reaction Steps

9.7 g. of KCN are dissolved in 150 ml. of DMF and a solution of 40 g. of 3-(4'-fluoro-4-biphenylyl)-butane-1,3-diol-1-benzenesulfonate in 150 ml. of DMF is added dropwise at 20°, while stirring. The mixture is heated to 80° for 6 hours, poured onto ice water and worked up in the customary manner to give 1-cyano-3-(4'-fluoro-4-biphenylyl)-butan-3-ol, m.p. 118° - 120°.

Provenance & Evidence