Phenyl isocyanate → HCID 13023187, compound

HRID 1439787Notes

Reaction equation

HRID 1439787 reaction equation
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24]1([N:30]=[C:31]=[O:32])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:31]([NH:30][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:32])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

Product 1

HCID 13023187HCID 13023187, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (3.0 g.) in acetone (100 ml.) is added phenyl isocyanate (1.08 g.). The reaction mixture is refluxed for 11/2 hours and then allowed to stand at room temperature overnight. The precipitate is collected, washed with ether and dried to afford 2.65 g. (65% yield) of 3-(3-carbomethoxythioureido)-4-(3-phenylureido)benzophenone as a white solid, m.p. 212° C., dec.

Workup

  1. temperatureThe reaction mixture is refluxed for 11/2 hours
  2. customThe precipitate is collected
  3. washwashed with ether
  4. customdried
  5. customto afford 2.65 g

Sources & evidence

ORD record
ord-a61c88645b924eb9ae246427d57a4462
Source dataset
uspto-grants-1977_11
Patent number
US04060636

Reaction notes

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