反应详情

To a solution of 3-amino-4-n-butylaminobenzophenone (2.38 g.) in diethyl ether (200 ml.) is added carbomethoxy isothiocyanate (1.4 g.). The reaction mixture is stirred at room temperature for 3 hours. The product is collected by filtration and dried to afford 0.2 g. of product, m.p. 160°-162° C., dec. The filtrate is allowed to stand overnight at room temperature and a second crop is collected amounting to 0.15 g., m.p. 162° C., dec. The total amount of 3-(3-carbomethoxythioureido)-4-n-butylamino-benzophenone obtained is 0.35 g. (10.2% yield).

1. filtrationThe product is collected by filtration
2. customdried
3. customto afford 0.2 g
4. waitto stand overnight at room temperature
5. customa second crop is collected amounting to 0.15 g