HuagongsheHuagongshe Chemistry Print Report · For research reference only
METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE → Methyl 7-{(3R)-3-[(oxan-2-yl)oxy]-5-oxocyclopent-1-en-1-yl}heptanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE | HCID 10800078 | — |
| Reactant | Norprostol, (-)- | HCID 10823960 | — |
| Product | Methyl 7-{(3R)-3-[(oxan-2-yl)oxy]-5-oxocyclopent-1-en-1-yl}heptanoate | HCID 13216834 | — |
Reaction Steps
Substitution of an equivalent quantity of methyl 7-(3(R)-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoate for the methyl 7-(3(S)-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoate and substantial repetition of the procedure detailed above affords methyl 7-(3(R)-tetrahydropyran-2-yloxy-5-oxocyclopent-1-en-1-yl)heptanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04060691 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-6331347f8f99434cb8de5d2fa19952ab |
| Source note | uspto-grants-1977_11 |