HCID 131719280, compound → HCID 178447749, compound

Participants

Reaction Steps

60 ml of a THF solution of 2.0M n-pentylmagnesium chloride was dripped into a mixture of 27.5 g (100 mmol) of 1-chloro-4-(2-(3,4-difluorophenyl)ethyl)-1-silacyclohexane and 200 ml of tetrahydrofuran (hereafter referred to as "THF"). The silacyclohexane rings of the target product thus obtained were a mixture of trans isomers and cis isomers. After a conventional after treatment, they were separated by means of chromatography to obtain 21.1 g of the trans isomers (yield 68%), which was the target product. This compound was in a liquid form at temperatures down to -60° C.

Provenance & Evidence