Water → HCID 18984240, compound

Participants

Reaction Steps

24.2 g of crude 2-(6-bromohexyl)-1,3-propanediol was dissolved in a mixture of 200 mL of benzene, 30 mL acetone, and 0.4 g toluene-4-sulfonic acid monohydrate (Fluka, puriss.) in a 1 L 1-necked round flask. While magnetically stirring and refluxing 1.4 mL of water was separated and collected in a Dean-Stark trap during 22 h. The solvents were removed by rotary evaporation under reduced pressure and the residue vacuum distilled to recover 14.65 g of 2,2-dimethyl-5-(6-bromohexyl)-m-dioxane with b.p. 96°-97° C./0.06 mbar.

Provenance & Evidence