P-Chloroacetophenone → HCID 22134085, compound

Participants

Reaction Conditions

Reaction Steps

Thiophenol (184 g) was gradually added dropwise to a suspension of 196 g of anhydrous potassium carbonate in 1,000 ml of DMF at room temperature, followed by dropwise addition of 200 g of 4'-chloroacetophenone. The resultant mixture was stirred with heating overnight at 100° C. The reaction mixture was poured into 2,000 ml of ice water and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. n-Hexane was added to the residue, and the resultant crystals were collected by filtration and washed with n-hexane. Thus was obtained 224 g of 4'-phenylthioacetophenone as crystals (m.p. 48°-50° C.).

Provenance & Evidence