HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxaspiro[4.5]decan-8-one → 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | HCID 178505835 | HCID 178505835 | — |
| Product | 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 22122104 | 42% |
Reaction Steps
This compound was prepared from 1,4-cyclohexanedione monoethylene ketal (15.6 g, 100 mmole) and 3,4-difluorophenyl magnesium bromide (100 mmole) in the usual mariner. The crude product was crystallized from isopropyl ether to give the product (42%, mp: 118°-120° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496847 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-968e0b33d582476d8da95924c5380d24 |
| Source note | uspto-grants-1996_03 |