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8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 22122104 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone | HCID 22122090 | 62% |
反応手順
A solution of 8-(3,4-difluorophenyl)-1,4- dioxaspiro[4.5]decan-8-ol (5.4 g, 20 mmole) in acetone-1N hydrochloric acid (1:1) was stirred for 4 hr. The acetone was removed in vacuo and the crude material crystallized from isopropyl ether to give the product (62%, mp: 84°-85° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05496847 |
| 出典データセット | uspto-grants-1996_03 |
| ORD ID | ord-c8733dd8ddab41caa8b4f38d885386c9 |
| 出典メモ | uspto-grants-1996_03 |