HCID 233935, compound → HCID 18984759, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 85% nitronium tetrafluoroborate (6.19 g, 39.6 mmol) in dichloromethane (60 mL) was added dropwise a solution of 6-chlorotetralin (6.0 g, 36 mmol) in dichloromethane (60 mL) over 15 min at 0° C. The mixture was stirred for 40 min at 0° C. and quenched by addition of ice-water (100 mL). The organic layer was separated, washed with water, dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography with 30:1~4:1 hexane/toluene to give 3.83 g of the title compound (54%): 1H NMR (CDCl3) δ7.65 (d, 1H, J=2.3 Hz), 7.30 (d, 1H, J=8.9 Hz), 2.90 (m, 4H), 1.76 (m, 4H).

Provenance & Evidence