Methanol → 7-Chloro-3-[p-tert-butoxycarbonylaminomethyl-o-(carboxymethoxy)phenylcarbamoylmethyl]-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylic acid

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A solution of methyl 1-benzenesulfonyl-7-chloro-3-[p-tert-butoxycarbonylaminomethyl-o-(tert-butoxycarbonylmethoxy)phenylcarbamoylmethyl]-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate (410 mg, 0.532 mmol) in a mixture of THF (6 mL ), MeOH (6 mL), and 1N LiOH (6 mL) was stirred for 17 h at room temperature, acidified to pH 2 with 5% KHSO4, and extracted with ethyl acetate. The organic layer was washed successively with water and brine, dried over magnesium sulfate, and concentrated. The residue was rinsed with diethyl ether and dried in vacuo to give 195 mg of the title compound (quant): 1H NMR (DMSO-d6) δ13.01 (br, 2H), 11.43 (s, 1H), 9.13 (s, 1H), 7.90 (d, 1H, J=8.3 Hz), 7.33 (d, 1H, J=6.3 Hz), 7.15 (s, 1H), 6.84 (s, 2H), 6.82 (d,1H, J=8.3 Hz), 4.05 (d, 2H, J=6.3 Hz), 3.88 (m, 1H), 3.32 (bs, 2H), 3.09 (mt, 1H, J=12.2 Hz), 2.79 (md, 1H, J=17.8 Hz), 2.68 (bd, 1H, J=13.9 Hz), 2.61 (bd, 1H, J=13.9 Hz), 2.09 (md 1H, J=14.2 Hz), 1.84 (m, 1H), 1.40 (s, 9H).

Provenance & Evidence