HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Chloro-2-methylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzene, 4-chloro-1-methyl-2-nitro- | HCID 6975 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Chloro-2-methylaniline | HCID 7260 | 89% |
Reaction Steps
To a solution of 2-nitro-4-chlorotoluene (86 g, 0.5 mol) in MeOH (250 mL) was added Fe powder (92 g, 3.65 mol) by portions over 45 min while refluxing gently. The mixture was stirred for 3 h at room temperature, poured into water (1.5 L) and extracted with AcOEt. The organic layers were dried over MgSO4 and concentrated in vacuo to give 63 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496843 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-56ebfbf913674fd4b595f3908f059b0b |
| Source note | uspto-grants-1996_03 |