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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1439933Generated: October 31, 2026

p-Toluenesulfonic acid monohydrate → cis-3-Hydroxy-2-phenylpiperidinium tosylate

https://huagongshe.com/reaction/1439933

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Toluenesulfonic acid monohydrateHCID 521998—
Reactant3-Hydroxy-2-phenylpiperidineHCID 18782643—
Productcis-3-Hydroxy-2-phenylpiperidinium tosylateHCID 86748915—

Reaction Steps

The mixture of cis- and trans-isomers of 3-hydroxy-2-phenylpiperidine (Description 1, (2b)) and 4-toluenesulfonic acid monohydrate was crystallized from methanol/ethyl acetate to give cis-3-hydroxy-2-phenylpiperidinium tosylate: mp 266°-267° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05496833
Source datasetuspto-grants-1996_03
ORD IDord-74467df5a935443da4315ef60ec9490d
Source noteuspto-grants-1996_03