p-Toluenesulfonic acid → HCID 22859270, compound

Participants

Reaction Steps

In benzene (100 ml ) was dissolved methyl (S )-2-[[N-benzyloxycarbonyl-(L )-phenylalanyl]amino]-5-hydroxyvalerate (2.85 g) followed by addition of p-toluenesulfonic acid (0.09 g), and the mixture was stirred under reflux for 1 hour. The reaction mixture was concentrated under reduced pressure to provide (S)-3-[[N-benzyloxycarbonyl-(L)-phenylalanyl]amino]-2-oxotetrahydropyran (chemical formula below) (2.0 g, 77%) m p 167°-169° C. optical rotation [α]D +43. 6° (c=0.50, CHCl3) ##STR36##

Provenance & Evidence