HCID 57242274, compound → HCID 22859256, compound

Participants

Reaction Steps

In methanol (50 ml) was suspended (2S, 3S)-2-acetoxy-3-[[N-valproyl-(L)-valyl]amino]tetrahydrofuran (0.55 g) followed by addition of concentrated hydrochloric acid (5 drops) and the mixture was stirred at room temperature for 1 hour. The reaction mixture was then concentrated under reduced pressure to obtain (2S,3S)-2-methoxy-3-[[N-valproyl-(L)-valyl]amino]tetrahydrofuran (chemical structure below) (0.38 g, 72%). As recrystallized from ethyl acetate, colorless crystals, m.p. 150°-156° C., optical rotation [α]D+ 18.5° (c=0.50, CHCl3).

Provenance & Evidence