HCID 57117802, compound → HCID 57001201, compound

Participants

Reaction Steps

In ethanol (100 ml) was dissolved (2S,3S)-2-acetoxy-3-[[N-[4-(N-benzyloxycarbonylamino)benzoyl]-(L)-leucyl]amino]tetrahydrofuran (1.0 g) and following addition of palladium-on-carbon (5%, 0.7 g), the catalytic hydrogenation was carried out at ambient temperature and atmospheric pressure. The catalyst was then filtered off and the filtrate was concentrated under reduced pressure to provide (2S,3S)-2-acetoxy-3-[[N-(4-aminobenzoyl)-(L)-leucyl]amino]tetrahydrofuran (chemical formula below) (0.61 g, 81%). As recrystallied from dichloromethane-isopropyl ether, colorless crystals, m.p. 148°-150° C. optical rotation [α]D -61.3° (C=0.29, CHCl3). ##STR68##

Provenance & Evidence