HCID 57320168, compound → HCID 57057802, compound

Participants

Reaction Steps

In ethanol (100 ml) was dissolved (2S,3S)-2-acetoxy-3-[[N-(4-nitrobenzenesulfonyl)-(L)-leucyl]amino]tetrahydrofuran (1.0 g) followed by addition of palladum-on-carbon (5%, 0.5 g) and the catalytic hydrogenation was carried out at ambient temperature and atmospheric pressure. The catalyst was filtered off and the filtrate was concentrated under reduced pressure to provide (2S,3S)-2-acetoxy-3-[[N-(4-aminobenzenesulfonyl)-(L)-leucyl]amino]tetrahydrofuran (chemical formula below) (0.7 g, 74%). As recrystallized from ethyl acetate-methonol-ether, colorless needles, m.p. 189°-190° C., optical rotation [α]D -59.2° (C=0.27, dimethyl sulfoxide) ##STR69##

Provenance & Evidence