HCID 56999328, compound → HCID 70115155, compound

Participants

Reaction Steps

In methanol (20 ml) was suspended (2S,3S)-2-acetoxy-3-[[N-(1-naphthylcarbamoyl)-(L)-leucyl]amino]tetrahydrofuran (0.1 g) and following addition of concentrated hydrochloric acid (5 drops), the mixture was stirred at room temperature for 1 hour. The reaction mixture was then concentrated under reduced pressure to give (3S)-2-methoxy-3-[[N-(1-naphthylcarbamoyl)-(L)-leucyl]amino]-tetrahydrofuran (chemical structure below) (0.08 g, 87%). As recrystallized from dichloromethane-isopropyl ether, colorless crystals, m.p. 184°-185° C., optical rotation [α]D +13.0° (C=0.27, CHCl3).

Provenance & Evidence