反应详情

1.0 g (6.85 mmol) of galactal is dissolved in about 1 ml of water, and 1-4 g of crushed molecular sieves, 25-75 ml of vinyl acetate and 800 mg of lipase from Candida cylindracea (Sigma) are added. The mixture is stirred at room temperature for about 45 min. Drying, filtration, concentration in vacuo and chromatography on silica gel (ethyl acetate/hexane 1:1) or crystallization (from ethyl acetate/hexane) yields 1.090 to 1.160 (85-90%) of the desired 6-O-acetylgalactal.

1. customDrying
2. filtrationfiltration, concentration in vacuo and chromatography
3. customon silica gel (ethyl acetate/hexane 1:1) or crystallization (from ethyl acetate/hexane)