Vinyl Acetate → HCID 11806454, compound

Participants

Reaction Steps

7.3 g (50 mmol) of glucal are taken up in 50 ml of ethyl acetate and 150 ml of vinyl acetate and stirred at room temperature with 2 g of lipase from Pseudomonas spec. (Lipase P, from Amano Pharmaceutical Co., Ltd., Nagoya, Japan). After the reaction is complete (TLC check, about 48 h) the reusable enzyme is filtered off, and the solvent is evaporated, The 3,6-di-O-acetylglucal which results in more than 90% yield can be used without further purification for synthetic purposes.

Provenance & Evidence