Vinyl Acetate → HCID 131719285, compound

Participants

Reaction Steps

1.0 g (4 mmol) of 6-O-tert.butyldimethylsilyl-glucal in 5-10 ml of vinyl acetate is stirred with 1.0 g of lipase from Pseudomonas spec. at room temperature for 3-4 hours. Filtration, concentration and chromatography (SiO2, ether/hexane 1:3) yields the desired 3-O-acetyl-6-O-tert.-butyldimethylsilyl-glucal in approximately 85% yield (0.98-1.0 g).

Provenance & Evidence