Vinyl chloroacetate → 6-O-acetyl-3-O-chloroacetyl-galactal

Participants

Reaction Steps

1.03 g (5.5 mmol) of 6-O-acetylgalactal are taken up in 10-15 ml of DME and 20-25 ml of vinyl chloroacetate and stirred with 1 g of lipase P (Pseudomonas spec.) at room temperature for 5-6 h. Filtering off the reusable enzyme, concentration of the solution and chromatography (SiO2, ether/hexane 1:2) result in 6-O-acetyl-3-O-chloroacetylgalactal in 80% yield.

Provenance & Evidence