HuagongsheHuagongshe Chemistry Print Report · For research reference only
Vinyl chloroacetate → 6-O-benzoyl-3-O-chloroacetylglucal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Vinyl chloroacetate | HCID 82156 | — |
| Reactant | 6-O-Benzoyl-D-glucal | HCID 14308105 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 6-O-benzoyl-3-O-chloroacetylglucal | HCID 14308111 | 82% |
Reaction Steps
1.0 g (4 mmol) of 6-O-benzoylglucal is dissolved in 2-5 ml of dimethoxyethane and 10-15 ml of vinyl chloroacetate and stirred with 1 g of lipase P (Amano) for 1-2 h. Filtering off the enzyme and chromatography on silica gel (ether/hexane 1:1) yield 6-O-benzoyl-3-O-chloroacetylglucal in 82-87% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496930 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-3d173144e76245a0a9cb1ef22c454d73 |
| Source note | uspto-grants-1996_03 |