HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus sulfide (P2S5) → HCID 22859298, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | HCID 18641671 | HCID 18641671 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 22859298 | HCID 22859298 | — |
Reaction Steps
5'-O-Acetyl-3'-fluorothymidine (400 mg, 1.4 mmoles) are heated under reflux for 24 hours with 933 mg of phosphorus pentasulfide in 32 mL of pyridine. After the solvent is driven off, the residue is fractionated by column chromatography on Kieselgel 40 and yields the desired compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496935 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-c2c0179bae274f0db048db8991a4ff93 |
| Source note | uspto-grants-1996_03 |